Home of:   CarbCruncher™ and NutriBold™   The natural ingredient Phase2 is the secret weapon if you will of CarbCruncher.  The question is: Does it work?   Definition:  Phase 2™ starch neutralizer is an extract from the white kidney bean (Phaseolus vulgaris).  It is a primary ingredient for a CarbCruncher designed to support weight loss and weight management by inhibiting the absorption of carbohydrates, reducing cravings for sugar, and supporting glucose metabolism and insulin efficiency. Phase 2® is backed by extensive clinical research proving its efficacy and safety. In addition, the white beans used to produce Phase 2® are non-GMO (genetically modified), and are processed under the strictest quality control. The extraction process uses purified water, without solvents, and virtually all impurities are removed. CLINICAL STUDIES Investigation of the Efficacy of Phase 2® a Purified Bean Extract from Pharmachem Laboratories Joe A. Vinson, PhD Department of Chemistry University of Chemistry Background Amylase is a digestive tract enzyme which breaks down starch into small units capable of being further degraded to glucose which is used for fuel for normal metabolism and body homeostasis. Clinical use of inhibitors of amylase activity has widespread appeal because a controlled reduction of starch digestion could influence carbohydrate uptake in diabetes and obesity, the latter of which is a current problem with 20% of the US population. Of course obesity is also linked to a greater risk of diabetes. A search in the National Library of Medicine Database reveals that there are 1098 articles concerning amylase inhibition. About 15 years ago there were a number of articles concerning the use of commercial bean-derived extracts. Also there were several articles indicating that some of these products which were good in vitro inhibitors were not effective when given to humans. Possible reasons for this failure were 1) insufficient activity; 2) destruction in the gastrointestinal tract; 3) suboptimal pH conditions; and 3) different gastric emptying rates of starch and inhibitor. A comprehensive experimental investigation by a group at the Mayo Clinic in 1985 found that the major reason commercial bean amylase inhibitors have failed to influence starch digestion in humans is their low antiamylase activity. Some inhibitors also have side effects such as diarrhea and an increase in intestinal gas. We have investigated the effectiveness of a new commercial bean extract (Phase 2) prepared by Pharmachem Laboratories using normal human subjects. Protocol Five males and five females (ages 21 to 57) participated in a double-blind placebo-controlled crossover study with informed consent. All subjects were employees at a commercial clinical laboratory and went about their duties as secretaries and technicians during the study. After an overnight fast, the participants were sampled for blood and then given in a random manner either 1) placebo consisting of 4 slices of white bread (60 grams of carbohydrate), 42 grams of soybean oil margarine and 4 grams of Sweet N’Low spread on the bread; 2) experimental comprising the placebo plus 1.5 grams of Phase 2 prepared by Pharmachem Laboratories. Plasma glucose was measured by a commercial enzyme kit (Sigma Chemical Company) from blood drawn at baseline, and every 30 minutes for 4 hours. After 1 week the regimen was repeated with the other supplement.? more Results and Discussion The subjects were normoglycemic as measured by fasting glucose concentration which averaged 98 mg/dl for the placebo and 104 for the Phase 2. From 60 to 120 minutes (as seen in the accompanying figure) the change in plasma glucose of the Phase 2 group from the baseline was ½ to 1/3 of the level of the placebo group. Phase 2 consumption caused the plasma glucose to return to baseline values 20 minutes earlier than the placebo without Phase 2. The average area under the plasma glucose-time curve from 0 to 150 minutes, which is a measure of absorption and metabolism, was 57% lower with Phase 2. Plotting the average change in glucose concentration from 30 minutes to 210 minutes, the area under the curve was positive for the placebo but negative for Phase2. This indicates that very little of the glucose from the starch in the bread was absorbed when co-ingested with Phase 2 and the glucose was cleared very rapidly. No side effects were observed with this product. The promising positive preliminary results of this single dose pilot study need to be confirmed. More control of physical activity is required to decrease the variability of plasma glucose between subjects. Ingestion of Phase 2 with a conventional meal should be examined. Other groups such as diabetic and obese should be studied with a single dose and also in a long-term supplementation study. All 7 clinical studies IntelliNutrients Home | Contact Us | Current Product | Ingredients | Wholesale | FAQ | Satisfied Customers |   | All Terms of Usage | Email Privacy | About us | Blog | Site Map | © 2007 IntelliNutrients. All Rights Reserved